US StockDetailed Quotes

Provided by Tiger Trade Technology Pte. Ltd.

Ionis Pharmaceuticals

54.21

-1.4400-2.59%

Post-market: 54.220.0100+0.02%18:32 EDT

Volume:2.18M

Turnover:119.32M

Market Cap:9.01B

PE:-15.58

High:56.16

Open:55.94

Low:54.16

Close:55.65

52wk High:86.74

52wk Low:50.01

Shares:166.18M

Float Shares:161.92M

Volume Ratio:0.49

T/O Rate:1.34%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.4800

EPS(LYR):-2.3812

ROE:-105.50%

ROA:-12.42%

PB:20.49

PE(LYR):-22.77

Loading ...

Overview Company News Filings

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Quarterly Report

Form 10-Q - Quarterly report [Sections 13 or 15(d)]

Employee Stock Ownership

Form S-8 - Securities to be offered to employees in employee benefit plans

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Major Issues Report

Form 8-K - Current report

Major Issues Report

Form 8-K - Current report

Major Issues Report

Form 8-K - Current report

Major Issues Report

Form 8-K - Current report

Quarterly Report

Form 10-Q - Quarterly report [Sections 13 or 15(d)]

Major Issues Report

Form 8-K - Current report

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Major Issues Report

Form 8-K - Current report

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Annual Report

Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405]

Major Issues Report

Form 8-K - Current report

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

{"basename":"","ssrTDKData":{"titleTemplate":"%s - Tiger Brokers","title":"Tiger Brokers HK | Online Trading in stocks, bonds & ETFS","description":"Discover Tiger Brokers HK, an online trading platform for stocks&ETFs, options&futures, bonds and crypto. Open an account to enjoy low commission trading today!","keywords":"tiger trading,tiger security,tiger broker hk,tigers co ltd,tiger trade hk,tiger brokers hk,stock broker,securities broker,online brokerage,hong kong broker,hk broker,online stock trading,online trading platform,stock trading platforms,trading application,stock trading,stock trading hong kong,buying stocks in hong kong,tiger brokers","social":{"ogDescription":"Discover Tiger Brokers HK, an online trading platform for stocks&ETFs, options&futures, bonds and crypto. Open an account to enjoy low commission trading today!","ogImage":"https://c1.itigergrowtha.com/portal5/static/media/og-logo.0a0bd8dc.png","ogUrl":"https://www.atigreclipse.com/stock/IONS/filings?page=7"},"companyName":"Tiger Brokers"},"pageData":{"isMobile":false,"isTiger":false,"isTTM":true,"region":"HKG","license":"TBHK","edition":"fundamental","symbol":"IONS","isAnalysisPage":false},"__swrFallback__":{"@#url:\"https://hq.skytigris.cn/stock_info/detail/global\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","market":"US","secType":"STK","nameCN":"Ionis Pharmaceuticals","latestPrice":54.21,"timestamp":1789156800000,"preClose":55.65,"halted":0,"volume":2175749,"hourTrading":{"tag":"盘后","latestPrice":54.22,"preClose":54.21,"latestTime":"18:32 EDT","volume":117566,"amount":6401863.016364,"timestamp":1789165934697,"change":0.01,"changeRate":0.000184,"amplitude":0.019738},"delay":0,"changeRate":-0.025876010781671118,"floatShares":161921007,"shares":166184322,"eps":-3.48,"marketStatus":"Post-Mkt","change":-1.44,"latestTime":"09-11 18:44:14 EDT","open":55.94,"high":56.16,"low":54.16,"amount":119320109.48531501,"amplitude":0.035939,"askPrice":55.27,"askSize":36,"bidPrice":54.21,"bidSize":2843,"shortable":3,"etf":0,"ttmEps":-3.48,"tradingStatus":3,"nextMarketStatus":{"tag":"Closed","tradingStatus":0,"beginTime":1789171200000},"marketStatusCode":4,"adr":0,"adrRate":0,"exchange":"NASDAQ","adjPreClose":55.65,"preHourTrading":{"tag":"盘前","latestPrice":55.97,"preClose":55.65,"latestTime":"09:29 EDT","volume":2574,"amount":143329.94676,"timestamp":1789133399999,"change":0.32,"changeRate":0.00575,"amplitude":0.018329},"postHourTrading":{"tag":"盘后","latestPrice":54.22,"preClose":54.21,"latestTime":"18:32 EDT","volume":117566,"amount":6401863.016364,"timestamp":1789165934697,"change":0.01,"changeRate":0.000184,"amplitude":0.019738},"volumeRatio":0.488059,"impliedVol":0.4195,"impliedVolPercentile":0.3745},"@#url:\"https://hq.skytigris.cn/stock_info/fundamental/all\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","floatShares":161921007,"roa":"-12.42%","roe":"-105.50%","lyrEps":-2.38125,"volumeRatio":0.488059,"shares":166184322,"dividePrice":0,"high":56.16,"amplitude":0.035939,"preClose":55.65,"low":54.16,"week52Low":50.005,"pbRate":"20.49","psRate":"10.31","week52High":86.74,"institutionHeld":0.92,"latestPrice":54.21,"committee":0.974991,"eps":-3.48,"divideRate":0,"volume":2175749,"delay":0,"ttmEps":-3.48,"open":55.94,"prevYearClose":79.11,"prevWeekClose":58.09,"prevMonthClose":60.36,"prevQuarterClose":79.29,"fiveDayClose":58.13,"twentyDayClose":55.87,"sixtyDayClose":73.09},"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/IONS\",params:#limit:5,,,undefined,":[{"market":"US","date":"2026-07-29","symbol":"IONS","fiscalQuarterEnding":"2026/06","expectedEps":-1.09,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1785297600000,"reportTimeType":"pre","actualEps":-0.7},{"market":"US","date":"2026-04-29","symbol":"IONS","fiscalQuarterEnding":"2026/03","expectedEps":-0.89,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1777435200000,"reportTimeType":"pre","actualEps":-0.56},{"market":"US","date":"2026-02-25","symbol":"IONS","fiscalQuarterEnding":"2025/12","expectedEps":-1.31,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1771995600000,"reportTimeType":"pre","actualEps":-1.41},{"market":"US","date":"2025-10-29","symbol":"IONS","fiscalQuarterEnding":"2025/09","expectedEps":-1.23,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1761710400000,"reportTimeType":"pre","actualEps":-0.8},{"market":"US","date":"2025-07-30","symbol":"IONS","fiscalQuarterEnding":"2025/06","expectedEps":-0.11,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1753848000000,"reportTimeType":"pre","actualEps":0.7}],"@#url:\"https://hq.skytigris.cn/fundamental/dividend/history\",params:#symbol:\"IONS\",market:\"US\",,,undefined,":[],"@#url:\"https://hq.skytigris.cn/fundamental/estimate/recommendation\",params:#symbol:\"IONS\",market:\"US\",delay:false,,,undefined,":{"strongBuy":0.2308,"buy":0.5385,"hold":0.2308,"sell":0,"strongSell":0,"meanLabel":"BUY","meanPercent":0.5385,"analysts":26,"updateTime":1787112000000},"@#url:\"https://hq.skytigris.cn/value_analysis/stock/IONS\",params:#withQuantilePoint:true,period:\"5year\",factor:\"peRate\",delay:false,algorithm:1,,,undefined,":{"brief":{"id":"IONS","date":"2026-09-10","current":-15.991379,"percent":0.65419,"low":-1664.931905,"twenty":-46.83029,"median":-17.982683,"eighty":-11.673442,"high":882.260453,"avg":-65.167353,"sd":366.235883,"marketCap":9309645718},"quantilePoints":[{"date":"2021-09-17","current":-9.553748,"twenty":-43.823694,"median":22.105712,"eighty":90.484478,"marketCap":5252105842},{"date":"2021-09-24","current":-9.294428,"twenty":-43.823694,"median":21.894477,"eighty":89.822908,"marketCap":5109546667},{"date":"2021-10-01","current":-8.61917,"twenty":-43.823694,"median":21.739571,"eighty":88.160122,"marketCap":4738328221},{"date":"2021-10-08","current":-8.752681,"twenty":-43.823694,"median":21.475528,"eighty":87.371554,"marketCap":4811725024},{"date":"2021-10-15","current":-9.012001,"twenty":-43.823694,"median":21.145012,"eighty":86.264015,"marketCap":4954284199},{"date":"2021-10-22","current":-7.815535,"twenty":-43.823694,"median":21.004285,"eighty":84.663252,"marketCap":4296535927},{"date":"2021-10-29","current":-8.182691,"twenty":-43.823694,"median":20.82218,"eighty":83.19244,"marketCap":4498377135},{"date":"2021-11-05","current":-7.827936,"twenty":-43.823694,"median":20.669316,"eighty":82.070133,"marketCap":4757365405},{"date":"2021-11-12","current":-7.595584,"twenty":-43.823694,"median":20.616507,"eighty":76.079084,"marketCap":4616155390},{"date":"2021-11-19","current":-7.432938,"twenty":-43.823694,"median":20.366546,"eighty":75.49578,"marketCap":4517308379},{"date":"2021-11-26","current":-6.749823,"twenty":-43.823694,"median":20.294106,"eighty":74.547727,"marketCap":4102150935},{"date":"2021-12-03","current":-6.131767,"twenty":-43.823694,"median":20.173015,"eighty":74.030875,"marketCap":3726532295},{"date":"2021-12-10","current":-6.847411,"twenty":-43.823694,"median":20.114106,"eighty":72.607318,"marketCap":4161459142},{"date":"2021-12-17","current":-7.542143,"twenty":-43.823694,"median":20.025743,"eighty":70.436541,"marketCap":4583677086},{"date":"2021-12-23","current":-7.600231,"twenty":-43.823694,"median":19.891562,"eighty":60.214071,"marketCap":4618979590},{"date":"2021-12-31","current":-7.070469,"twenty":-43.823694,"median":19.796653,"eighty":53.012098,"marketCap":4297020756},{"date":"2022-01-07","current":-7.058851,"twenty":-43.611673,"median":19.749198,"eighty":51.923862,"marketCap":4289960255},{"date":"2022-01-14","current":-7.686201,"twenty":-43.611673,"median":19.64938,"eighty":51.147099,"marketCap":4671227296},{"date":"2022-01-21","current":-6.942675,"twenty":-43.611673,"median":19.61175,"eighty":50.934296,"marketCap":4219355248},{"date":"2022-01-28","current":-7.360909,"twenty":-43.611673,"median":19.468798,"eighty":50.847883,"marketCap":4473533275},{"date":"2022-02-04","current":-7.319085,"twenty":-43.611673,"median":19.28882,"eighty":50.5876,"marketCap":4448115472},{"date":"2022-02-11","current":-7.639731,"twenty":-43.611673,"median":19.164904,"eighty":50.143461,"marketCap":4642985293},{"date":"2022-02-18","current":-7.497996,"twenty":-43.611673,"median":18.965356,"eighty":49.908881,"marketCap":4556847184},{"date":"2022-02-25","current":-157.459445,"twenty":-44.533501,"median":18.77393,"eighty":49.713145,"marketCap":4502867744},{"date":"2022-03-04","current":-160.035874,"twenty":-45.829592,"median":18.155386,"eighty":49.32903,"marketCap":4576545882},{"date":"2022-03-11","current":-159.49086,"twenty":-46.633425,"median":-6.144547,"eighty":48.69515,"marketCap":4560960122},{"date":"2022-03-18","current":-174.652153,"twenty":-47.12015,"median":-6.881102,"eighty":48.427938,"marketCap":4994527626},{"date":"2022-03-25","current":-181.687786,"twenty":-47.927671,"median":-7.000763,"eighty":48.265452,"marketCap":5195725619},{"date":"2022-04-01","current":-192.736702,"twenty":-48.230031,"median":-7.040263,"eighty":47.833218,"marketCap":5511691480},{"date":"2022-04-08","current":-198.781401,"twenty":-48.689101,"median":-7.082087,"eighty":47.228668,"marketCap":5684551727},{"date":"2022-04-14","current":-202.992871,"twenty":-49.716018,"median":-7.119262,"eighty":46.918857,"marketCap":5804987145},{"date":"2022-04-22","current":-206.852389,"twenty":-50.435043,"median":-7.237762,"eighty":46.570634,"marketCap":5915357781},{"date":"2022-04-29","current":-182.216483,"twenty":-51.591015,"median":-7.300497,"eighty":46.245658,"marketCap":5210844764},{"date":"2022-05-06","current":-1322.183946,"twenty":-128.214398,"median":-7.341159,"eighty":45.925265,"marketCap":5147262100},{"date":"2022-05-13","current":-1314.170709,"twenty":-130.326929,"median":-7.37485,"eighty":45.90793,"marketCap":5116066572},{"date":"2022-05-20","current":-1438.375868,"twenty":-130.86667,"median":-7.37485,"eighty":45.90793,"marketCap":5599597254},{"date":"2022-05-27","current":-1370.6276,"twenty":-132.625178,"median":-7.37485,"eighty":45.90793,"marketCap":5335853246},{"date":"2022-06-03","current":-1316.720376,"twenty":-134.128325,"median":-7.37485,"eighty":45.90793,"marketCap":5125992422},{"date":"2022-06-10","current":-1266.091293,"twenty":-137.45382,"median":-7.37485,"eighty":45.90793,"marketCap":4928893405},{"date":"2022-06-17","current":-1284.303193,"twenty":-139.005646,"median":-7.37485,"eighty":45.90793,"marketCap":4999792332},{"date":"2022-06-24","current":-1429.634156,"twenty":-139.862338,"median":-7.360909,"eighty":45.909339,"marketCap":5565565769},{"date":"2022-07-01","current":-1386.289834,"twenty":-141.353878,"median":-7.360909,"eighty":45.909339,"marketCap":5396826323},{"date":"2022-07-08","current":-1353.144176,"twenty":-142.456573,"median":-7.360909,"eighty":45.909339,"marketCap":5267790276},{"date":"2022-07-15","current":-1431.819584,"twenty":-143.808127,"median":-7.360909,"eighty":45.909339,"marketCap":5574073640},{"date":"2022-07-22","current":-1387.746786,"twenty":-144.656772,"median":-7.360909,"eighty":45.909339,"marketCap":5402498237},{"date":"2022-07-29","current":-1368.077934,"twenty":-146.022974,"median":-7.360909,"eighty":45.909339,"marketCap":5325927396},{"date":"2022-08-05","current":-1664.567667,"twenty":-147.819198,"median":-7.360909,"eighty":45.909339,"marketCap":6480161927},{"date":"2022-08-12","current":-222.342663,"twenty":-148.698169,"median":-7.360909,"eighty":45.909339,"marketCap":6259613005},{"date":"2022-08-19","current":-221.838485,"twenty":-149.407406,"median":-7.360909,"eighty":45.909339,"marketCap":6245418872},{"date":"2022-08-26","current":-213.519542,"twenty":-149.883165,"median":-7.360909,"eighty":45.909339,"marketCap":6011215664},{"date":"2022-09-02","current":-218.006729,"twenty":-150.165357,"median":-7.360909,"eighty":45.909339,"marketCap":6137543455},{"date":"2022-09-09","current":-236.157151,"twenty":-151.092649,"median":-7.360909,"eighty":45.909339,"marketCap":6648532271},{"date":"2022-09-16","current":-233.585841,"twenty":-153.529951,"median":-7.360909,"eighty":45.909339,"marketCap":6576142189},{"date":"2022-09-23","current":-217.956312,"twenty":-156.46647,"median":-7.360909,"eighty":45.909339,"marketCap":6136124041},{"date":"2022-09-30","current":-222.998095,"twenty":-157.969129,"median":-7.360909,"eighty":45.909339,"marketCap":6278065379},{"date":"2022-10-07","current":-231.569128,"twenty":-159.577078,"median":-7.360909,"eighty":45.909339,"marketCap":6519365654},{"date":"2022-10-14","current":-233.737095,"twenty":-160.082841,"median":-7.360909,"eighty":45.909339,"marketCap":6580400429},{"date":"2022-10-21","current":-226.62818,"twenty":-160.43291,"median":-7.360909,"eighty":45.909339,"marketCap":6380263143},{"date":"2022-10-28","current":-224.913973,"twenty":-161.94987,"median":-7.360909,"eighty":45.909339,"marketCap":6332003088},{"date":"2022-11-04","current":-209.486115,"twenty":-162.370971,"median":-7.360909,"eighty":45.909339,"marketCap":5897662593},{"date":"2022-11-11","current":839.185498,"twenty":-162.756411,"median":-7.319085,"eighty":46.031035,"marketCap":6143677032},{"date":"2022-11-18","current":836.080997,"twenty":-162.756411,"median":-7.284232,"eighty":46.34415,"marketCap":6120948978},{"date":"2022-11-25","current":806.394204,"twenty":-162.756411,"median":-7.219174,"eighty":46.64061,"marketCap":5903611964},{"date":"2022-12-02","current":782.334319,"twenty":-162.756411,"median":-7.102998,"eighty":47.141347,"marketCap":5727469547},{"date":"2022-12-09","current":727.617484,"twenty":-162.756411,"median":-7.058851,"eighty":47.387939,"marketCap":5326887600},{"date":"2022-12-16","current":750.125118,"twenty":-162.756411,"median":-7.014704,"eighty":48.047842,"marketCap":5491665989},{"date":"2022-12-23","current":740.423552,"twenty":-162.756411,"median":-6.972881,"eighty":48.293594,"marketCap":5420640821},{"date":"2022-12-30","current":732.85633,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5365241190},{"date":"2023-01-06","current":786.214945,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5755879614},{"date":"2023-01-13","current":773.214846,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5660705889},{"date":"2023-01-20","current":790.871697,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5789971695},{"date":"2023-01-27","current":776.513379,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5684854446},{"date":"2023-02-03","current":793.976198,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5812699749},{"date":"2023-02-10","current":756.722183,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5539963104},{"date":"2023-02-17","current":748.96093,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5483142969},{"date":"2023-02-24","current":-18.915876,"twenty":-162.756411,"median":-6.942675,"eighty":48.318169,"marketCap":5102028010},{"date":"2023-03-03","current":-19.398181,"twenty":-162.756411,"median":-7.010057,"eighty":48.167441,"marketCap":5232116143},{"date":"2023-03-10","current":-17.998968,"twenty":-162.756411,"median":-7.047233,"eighty":47.522459,"marketCap":4854717602},{"date":"2023-03-17","current":-18.645574,"twenty":-162.756411,"median":-7.096027,"eighty":47.151665,"marketCap":5029121473},{"date":"2023-03-24","current":-17.993668,"twenty":-162.756411,"median":-7.188968,"eighty":46.719576,"marketCap":4853288062},{"date":"2023-03-31","current":-18.942377,"twenty":-162.739653,"median":-7.283071,"eighty":46.447558,"marketCap":5109175709},{"date":"2023-04-06","current":-19.392881,"twenty":-162.739653,"median":-7.309791,"eighty":46.139197,"marketCap":5230686603},{"date":"2023-04-14","current":-19.906986,"twenty":-162.756411,"median":-7.388791,"eighty":45.881909,"marketCap":5369351977},{"date":"2023-04-21","current":-19.158378,"twenty":-162.756411,"median":-7.484055,"eighty":45.586713,"marketCap":5167435947},{"date":"2023-04-28","current":-18.691747,"twenty":-162.756411,"median":-7.542143,"eighty":45.238708,"marketCap":5041575343},{"date":"2023-05-05","current":-15.654507,"twenty":-162.722895,"median":-7.581643,"eighty":45.096531,"marketCap":5148454369},{"date":"2023-05-12","current":-15.484823,"twenty":-162.005118,"median":-7.581643,"eighty":45.096531,"marketCap":5092648444},{"date":"2023-05-19","current":-15.937315,"twenty":-160.611822,"median":-7.581643,"eighty":45.096531,"marketCap":5241464245},{"date":"2023-05-26","current":-17.042442,"twenty":-160.205418,"median":-7.581643,"eighty":45.096531,"marketCap":5604918222},{"date":"2023-06-02","current":-18.682728,"twenty":-159.773437,"median":-7.581643,"eighty":45.096531,"marketCap":6144375503},{"date":"2023-06-09","current":-18.121463,"twenty":-159.192484,"median":-7.581643,"eighty":45.096531,"marketCap":5959786673},{"date":"2023-06-16","current":-18.138866,"twenty":-156.985977,"median":-7.581643,"eighty":45.096531,"marketCap":5965510357},{"date":"2023-06-23","current":-17.925673,"twenty":-155.435521,"median":-7.578157,"eighty":45.109315,"marketCap":5895395220},{"date":"2023-06-30","current":-17.886515,"twenty":-151.740635,"median":-7.574672,"eighty":45.122099,"marketCap":5882516929},{"date":"2023-07-07","current":-18.169323,"twenty":-150.657265,"median":-7.574672,"eighty":45.122099,"marketCap":5975526805},{"date":"2023-07-14","current":-18.560903,"twenty":-150.083568,"median":-7.574672,"eighty":45.122099,"marketCap":6104309711},{"date":"2023-07-21","current":-17.821251,"twenty":-149.641501,"median":-7.574672,"eighty":45.122099,"marketCap":5861053112},{"date":"2023-07-28","current":-16.750932,"twenty":-149.090615,"median":-7.574672,"eighty":45.122099,"marketCap":5509046504},{"date":"2023-08-04","current":-17.151214,"twenty":-148.303568,"median":-7.574672,"eighty":45.122099,"marketCap":5640691252},{"date":"2023-08-11","current":-18.467972,"twenty":-148.00823,"median":-7.574672,"eighty":45.122099,"marketCap":5707249602},{"date":"2023-08-18","current":-18.147959,"twenty":-147.735407,"median":-7.574672,"eighty":45.122099,"marketCap":5608354519},{"date":"2023-08-25","current":-18.463334,"twenty":-145.579013,"median":-7.574672,"eighty":45.122099,"marketCap":5705816340},{"date":"2023-09-01","current":-18.676675,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5771746396},{"date":"2023-09-08","current":-18.727692,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5787512279},{"date":"2023-09-15","current":-20.239635,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":6254755717},{"date":"2023-09-22","current":-19.701643,"twenty":-144.797122,"median":-7.574672,"eighty":45.122099,"marketCap":6088497315},{"date":"2023-09-29","current":-21.454756,"twenty":-143.400598,"median":-7.574672,"eighty":45.122099,"marketCap":6630270382},{"date":"2023-10-06","current":-21.728389,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6714832844},{"date":"2023-10-13","current":-21.38055,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6607338188},{"date":"2023-10-20","current":-21.593891,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6673268244},{"date":"2023-10-27","current":-21.16257,"twenty":-143.300049,"median":-7.55957,"eighty":45.146419,"marketCap":6539974871},{"date":"2023-11-03","current":-15.297336,"twenty":-140.032184,"median":-7.55957,"eighty":45.146419,"marketCap":6267655075},{"date":"2023-11-10","current":-16.577399,"twenty":-22.395314,"median":-7.55957,"eighty":45.146419,"marketCap":6787665949},{"date":"2023-11-17","current":-17.008391,"twenty":-21.672735,"median":-7.55957,"eighty":45.146419,"marketCap":6964136656},{"date":"2023-11-24","current":-17.460406,"twenty":-21.484438,"median":-7.55957,"eighty":45.146419,"marketCap":7149215689},{"date":"2023-12-01","current":-17.334262,"twenty":-21.2275,"median":-7.55957,"eighty":45.146419,"marketCap":7097565726},{"date":"2023-12-08","current":-17.334262,"twenty":-20.411236,"median":-7.572349,"eighty":45.140651,"marketCap":7097565726},{"date":"2023-12-15","current":-17.456902,"twenty":-20.127399,"median":-7.572349,"eighty":45.140651,"marketCap":7147780968},{"date":"2023-12-22","current":-17.208119,"twenty":-19.907658,"median":-7.572349,"eighty":45.140651,"marketCap":7045915764},{"date":"2023-12-29","current":-17.695174,"twenty":-19.76602,"median":-7.55957,"eighty":45.146419,"marketCap":7245342009},{"date":"2024-01-05","current":-18.038565,"twenty":-19.665059,"median":-7.54679,"eighty":45.152187,"marketCap":7385944686},{"date":"2024-01-12","current":-18.763892,"twenty":-19.458602,"median":-7.54679,"eighty":45.152187,"marketCap":7682931972},{"date":"2024-01-19","current":-17.747734,"twenty":-19.2678,"median":-7.544467,"eighty":45.157955,"marketCap":7266862827},{"date":"2024-01-26","current":-18.073605,"twenty":-19.134896,"median":-7.54679,"eighty":45.152187,"marketCap":7400291898},{"date":"2024-02-02","current":-17.859862,"twenty":-19.007278,"median":-7.54679,"eighty":45.152187,"marketCap":7312773905},{"date":"2024-02-09","current":-17.512966,"twenty":-18.941814,"median":-7.54679,"eighty":45.152187,"marketCap":7170736507},{"date":"2024-02-16","current":-15.866089,"twenty":-18.881956,"median":-7.54679,"eighty":45.152187,"marketCap":6496417548},{"date":"2024-02-23","current":-17.500434,"twenty":-18.811317,"median":-7.54679,"eighty":45.152187,"marketCap":6410164032},{"date":"2024-03-01","current":-17.989873,"twenty":-18.791838,"median":-7.578157,"eighty":45.146419,"marketCap":6589438742},{"date":"2024-03-08","current":-17.774998,"twenty":-18.791838,"median":-7.603716,"eighty":45.146419,"marketCap":6510732771},{"date":"2024-03-15","current":-16.784182,"twenty":-18.791838,"median":-7.673842,"eighty":45.146419,"marketCap":6147810797},{"date":"2024-03-22","current":-17.010995,"twenty":-18.791838,"median":-7.777023,"eighty":45.146419,"marketCap":6230889321},{"date":"2024-03-28","current":-17.771018,"twenty":-18.791838,"median":-7.81825,"eighty":45.146419,"marketCap":6509275254},{"date":"2024-04-05","current":-17.042828,"twenty":-18.796083,"median":-7.904612,"eighty":45.152187,"marketCap":6242549465},{"date":"2024-04-12","current":-16.911516,"twenty":-18.796083,"median":-8.182691,"eighty":45.152187,"marketCap":6194451372},{"date":"2024-04-19","current":-16.239034,"twenty":-18.796083,"median":-8.560117,"eighty":45.152187,"marketCap":5948130835},{"date":"2024-04-26","current":-16.659633,"twenty":-18.791838,"median":-8.646128,"eighty":45.146419,"marketCap":6102190447},{"date":"2024-05-03","current":-17.157352,"twenty":-18.791838,"median":-8.845112,"eighty":45.146419,"marketCap":6284497762},{"date":"2024-05-10","current":-14.961134,"twenty":-18.791838,"median":-9.293144,"eighty":45.146419,"marketCap":5756535778},{"date":"2024-05-17","current":-14.25989,"twenty":-18.791838,"median":-9.334225,"eighty":45.146419,"marketCap":5486720952},{"date":"2024-05-24","current":-14.40393,"twenty":-18.791838,"median":-9.552464,"eighty":45.146419,"marketCap":5542142376},{"date":"2024-05-31","current":-13.854306,"twenty":-18.791838,"median":-9.739892,"eighty":45.146419,"marketCap":5330665890},{"date":"2024-06-07","current":-15.112755,"twenty":-18.791838,"median":-9.90935,"eighty":45.146419,"marketCap":5814874119},{"date":"2024-06-14","current":-15.586568,"twenty":-18.796083,"median":-9.987659,"eighty":45.152187,"marketCap":5997181434},{"date":"2024-06-21","current":-15.469062,"twenty":-18.800329,"median":-10.068299,"eighty":45.157955,"marketCap":5951969220},{"date":"2024-06-28","current":-17.902568,"twenty":-18.809069,"median":-10.099656,"eighty":45.171414,"marketCap":6888299589},{"date":"2024-07-05","current":-17.284716,"twenty":-18.809069,"median":-10.146845,"eighty":45.171414,"marketCap":6650570851},{"date":"2024-07-12","current":-17.932892,"twenty":-18.809069,"median":-10.187925,"eighty":45.171414,"marketCap":6899967258},{"date":"2024-07-15","current":-18.194437,"twenty":-18.809069,"median":-10.208466,"eighty":45.171414,"marketCap":7000600896},{"date":"2024-08-02","current":-20.490271,"twenty":-18.868176,"median":-10.389456,"eighty":45.307924,"marketCap":7484809124},{"date":"2024-08-09","current":-18.992918,"twenty":-18.884076,"median":-10.451704,"eighty":45.307924,"marketCap":6946488933},{"date":"2024-08-16","current":-18.655115,"twenty":-18.884076,"median":-10.488762,"eighty":45.307924,"marketCap":6822940561},{"date":"2024-08-23","current":-19.004911,"twenty":-18.92096,"median":-10.554325,"eighty":45.307924,"marketCap":6950875266},{"date":"2024-08-30","current":-19.948361,"twenty":-18.942377,"median":-10.636992,"eighty":45.307924,"marketCap":7295933440},{"date":"2024-09-06","current":-19.248769,"twenty":-18.979477,"median":-10.675476,"eighty":45.307924,"marketCap":7040064031},{"date":"2024-09-13","current":-17.667381,"twenty":-18.992918,"median":-10.762419,"eighty":45.307924,"marketCap":6461685590},{"date":"2024-09-20","current":-18.408188,"twenty":-18.992918,"median":-10.826557,"eighty":45.307924,"marketCap":6732629014},{"date":"2024-09-27","current":-17.701837,"twenty":-18.992918,"median":-11.068858,"eighty":45.307924,"marketCap":6474287610},{"date":"2024-10-04","current":-16.284829,"twenty":-18.992918,"median":-11.242743,"eighty":45.307924,"marketCap":5956029551},{"date":"2024-10-11","current":-16.345127,"twenty":-18.992918,"median":-12.040191,"eighty":45.307924,"marketCap":5978083085},{"date":"2024-10-18","current":-16.577706,"twenty":-18.992918,"median":-13.03948,"eighty":45.307924,"marketCap":6063146718},{"date":"2024-10-25","current":-16.698302,"twenty":-18.992918,"median":-13.446915,"eighty":45.307924,"marketCap":6107253787},{"date":"2024-10-31","current":-16.909346,"twenty":-18.992918,"median":-13.562755,"eighty":45.307924,"marketCap":6184441157},{"date":"2024-11-08","current":-16.902216,"twenty":-18.995317,"median":-13.748329,"eighty":45.31946,"marketCap":6072729658},{"date":"2024-11-15","current":-16.383322,"twenty":-18.995317,"median":-13.840323,"eighty":45.31946,"marketCap":5878515995},{"date":"2024-11-22","current":-14.935534,"twenty":-18.995317,"median":-14.176174,"eighty":45.31946,"marketCap":5359033920},{"date":"2024-11-29","current":-15.723236,"twenty":-18.995317,"median":-14.25989,"eighty":45.31946,"marketCap":5641670064},{"date":"2024-12-06","current":-16.172094,"twenty":-18.995317,"median":-14.506273,"eighty":45.31946,"marketCap":5802725297},{"date":"2024-12-13","current":-16.286509,"twenty":-18.995317,"median":-14.813304,"eighty":45.31946,"marketCap":5843778591},{"date":"2024-12-20","current":-15.661628,"twenty":-18.995317,"median":-14.935534,"eighty":45.31946,"marketCap":5619564444},{"date":"2024-12-27","current":-15.98727,"twenty":-18.995317,"median":-15.08243,"eighty":45.31946,"marketCap":5736408436},{"date":"2025-01-03","current":-15.265577,"twenty":-18.995317,"median":-15.112755,"eighty":45.31946,"marketCap":5477456886},{"date":"2025-01-10","current":-15.005943,"twenty":-18.997715,"median":-15.244128,"eighty":45.330996,"marketCap":5384297486},{"date":"2025-01-17","current":-14.205039,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5096924424},{"date":"2025-01-24","current":-15.164364,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5441140510},{"date":"2025-01-31","current":-14.662699,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5261137602},{"date":"2025-02-07","current":-14.359059,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5152188474},{"date":"2025-02-14","current":-13.35573,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4792182660},{"date":"2025-02-21","current":-11.446164,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5196558396},{"date":"2025-02-28","current":-10.979464,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4983545602},{"date":"2025-03-07","current":-12.044139,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5466798509},{"date":"2025-03-14","current":-11.522308,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5229940998},{"date":"2025-03-21","current":-11.46277,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5202916987},{"date":"2025-03-28","current":-11.109046,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5042362567},{"date":"2025-04-04","current":-9.988335,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4533675297},{"date":"2025-04-11","current":-9.354433,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4245949060},{"date":"2025-04-17","current":-9.928797,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4506651286},{"date":"2025-04-25","current":-10.356068,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4700588308},{"date":"2025-05-02","current":-11.018739,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5046935029},{"date":"2025-05-09","current":-11.380123,"twenty":-19.000114,"median":-15.297336,"eighty":45.26178,"marketCap":5212460492},{"date":"2025-05-16","current":-11.463519,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5250658676},{"date":"2025-05-23","current":-11.55734,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5293631632},{"date":"2025-05-30","current":-11.626837,"twenty":-19.000114,"median":-15.297336,"eighty":45.007986,"marketCap":5325463452},{"date":"2025-06-06","current":-12.24536,"twenty":-19.000114,"median":-15.297336,"eighty":44.117786,"marketCap":5608766648},{"date":"2025-06-13","current":-12.377404,"twenty":-19.000114,"median":-15.297336,"eighty":-6.098308,"marketCap":5669247106},{"date":"2025-06-20","current":-12.860408,"twenty":-19.002512,"median":-15.301886,"eighty":-6.769341,"marketCap":5890478253},{"date":"2025-06-27","current":-13.82294,"twenty":-19.002512,"median":-15.301886,"eighty":-6.989146,"marketCap":6331348958},{"date":"2025-07-03","current":-14.941841,"twenty":-19.002512,"median":-15.301886,"eighty":-7.017492,"marketCap":6843841257},{"date":"2025-07-11","current":-14.7264,"twenty":-19.002512,"median":-15.301886,"eighty":-7.061175,"marketCap":6745162615},{"date":"2025-07-18","current":-14.653429,"twenty":-19.002512,"median":-15.301886,"eighty":-7.105786,"marketCap":6711739204},{"date":"2025-07-25","current":-14.646479,"twenty":-19.002512,"median":-15.301886,"eighty":-7.221033,"marketCap":6708556022},{"date":"2025-08-01","current":-25.541485,"twenty":-19.026904,"median":-15.342587,"eighty":-7.288415,"marketCap":6850635022},{"date":"2025-08-08","current":-24.394555,"twenty":-19.059439,"median":-15.406519,"eighty":-7.31955,"marketCap":6543009950},{"date":"2025-08-15","current":-25.464231,"twenty":-19.208439,"median":-15.476942,"eighty":-7.439444,"marketCap":6829914162},{"date":"2025-08-22","current":-25.693023,"twenty":-19.327123,"median":-15.573133,"eighty":-7.500784,"marketCap":6891279785},{"date":"2025-08-29","current":-25.32755,"twenty":-19.462842,"median":-15.656683,"eighty":-7.572814,"marketCap":6793254179},{"date":"2025-09-05","current":-35.269594,"twenty":-19.610183,"median":-15.723236,"eighty":-7.595584,"marketCap":9459869441},{"date":"2025-09-12","current":-38.056694,"twenty":-19.731561,"median":-15.763036,"eighty":-7.642541,"marketCap":10207414305},{"date":"2025-09-19","current":-36.689886,"twenty":-19.905803,"median":-15.876073,"eighty":-7.741966,"marketCap":9840814478},{"date":"2025-09-26","current":-37.420831,"twenty":-20.021346,"median":-16.03996,"eighty":-7.801291,"marketCap":10036865690},{"date":"2025-10-03","current":-40.647687,"twenty":-20.250766,"median":-16.203648,"eighty":-7.855354,"marketCap":10902360063},{"date":"2025-10-10","current":-41.758962,"twenty":-20.936243,"median":-16.267488,"eighty":-8.057965,"marketCap":11200421661},{"date":"2025-10-17","current":-43.422902,"twenty":-21.44548,"median":-16.302057,"eighty":-8.466659,"marketCap":11646717103},{"date":"2025-10-24","current":-42.489907,"twenty":-21.627284,"median":-16.365719,"eighty":-8.619683,"marketCap":11396472873},{"date":"2025-10-31","current":-46.865674,"twenty":-22.311833,"median":-16.491552,"eighty":-8.824572,"marketCap":12013640728},{"date":"2025-11-07","current":-46.821444,"twenty":-24.565703,"median":-16.551864,"eighty":-9.220997,"marketCap":12002302521},{"date":"2025-11-14","current":-44.129685,"twenty":-25.310911,"median":-16.577552,"eighty":-9.310347,"marketCap":11312291607},{"date":"2025-11-21","current":-46.202213,"twenty":-25.459477,"median":-16.623152,"eighty":-9.406991,"marketCap":11843567616},{"date":"2025-11-28","current":-52.274467,"twenty":-25.606854,"median":-16.659586,"eighty":-9.54788,"marketCap":13400141532},{"date":"2025-12-05","current":-51.693149,"twenty":-25.977676,"median":-16.714478,"eighty":-9.709339,"marketCap":13251125091},{"date":"2025-12-12","current":-50.00606,"twenty":-36.254884,"median":-16.738094,"eighty":-9.817591,"marketCap":12818653462},{"date":"2025-12-19","current":-49.051939,"twenty":-36.458718,"median":-16.773398,"eighty":-9.930898,"marketCap":12574072128},{"date":"2025-12-26","current":-50.960181,"twenty":-37.51116,"median":-16.804783,"eighty":-9.964551,"marketCap":13063234795},{"date":"2026-01-02","current":-49.987104,"twenty":-38.080464,"median":-16.872737,"eighty":-9.994875,"marketCap":12813794230},{"date":"2026-01-09","current":-51.522544,"twenty":-40.33867,"median":-16.913584,"eighty":-10.055281,"marketCap":13207392005},{"date":"2026-01-16","current":-48.786554,"twenty":-41.579494,"median":-16.936559,"eighty":-10.101905,"marketCap":12506042883},{"date":"2026-01-23","current":-51.680511,"twenty":-42.352038,"median":-16.969214,"eighty":-10.147872,"marketCap":13247885603},{"date":"2026-01-30","current":-53.001116,"twenty":-43.304049,"median":-17.016336,"eighty":-10.177655,"marketCap":13586412084},{"date":"2026-02-06","current":-52.748369,"twenty":-43.896106,"median":-17.042828,"eighty":-10.276361,"marketCap":13521622327},{"date":"2026-02-13","current":-51.674193,"twenty":-45.89007,"median":-17.08842,"eighty":-10.365331,"marketCap":13246265859},{"date":"2026-02-20","current":-52.536693,"twenty":-46.437268,"median":-17.113581,"eighty":-10.415699,"marketCap":13467360905},{"date":"2026-02-27","current":-34.265449,"twenty":-46.808807,"median":-17.154283,"eighty":-10.419492,"marketCap":13055136075},{"date":"2026-03-06","current":-32.554417,"twenty":-46.808807,"median":-17.180856,"eighty":-10.419492,"marketCap":12415831546},{"date":"2026-03-13","current":-31.332977,"twenty":-46.808807,"median":-17.209871,"eighty":-10.419492,"marketCap":11949990075},{"date":"2026-03-20","current":-30.891179,"twenty":-46.808807,"median":-17.218631,"eighty":-10.419492,"marketCap":11781494224},{"date":"2026-03-27","current":-32.155933,"twenty":-46.808807,"median":-17.24834,"eighty":-10.419492,"marketCap":12263854896},{"date":"2026-04-02","current":-32.541423,"twenty":-46.808807,"median":-17.287579,"eighty":-10.419492,"marketCap":12410875786},{"date":"2026-04-10","current":-33.104499,"twenty":-46.808807,"median":-17.33251,"eighty":-10.419492,"marketCap":12625625400},{"date":"2026-04-17","current":-32.597731,"twenty":-46.808807,"median":-17.370954,"eighty":-10.419492,"marketCap":12432350747},{"date":"2026-04-24","current":-32.090963,"twenty":-46.808807,"median":-17.417852,"eighty":-10.419492,"marketCap":12239076094},{"date":"2026-05-01","current":-37.78562,"twenty":-46.808807,"median":-17.460406,"eighty":-10.419492,"marketCap":12355028686},{"date":"2026-05-08","current":-38.422456,"twenty":-46.808807,"median":-17.499692,"eighty":-10.425443,"marketCap":12563259507},{"date":"2026-05-15","current":-38.250612,"twenty":-46.808807,"median":-17.54086,"eighty":-10.441583,"marketCap":12507070238},{"date":"2026-05-22","current":-38.301154,"twenty":-46.808807,"median":-17.626193,"eighty":-10.45769,"marketCap":12523596493},{"date":"2026-05-29","current":-39.084564,"twenty":-46.821444,"median":-17.65446,"eighty":-10.515842,"marketCap":12779753455},{"date":"2026-06-05","current":-37.972628,"twenty":-46.808807,"median":-17.690774,"eighty":-10.584827,"marketCap":12416175832},{"date":"2026-06-12","current":-37.31052,"twenty":-46.808807,"median":-17.738974,"eighty":-10.668419,"marketCap":12199681883},{"date":"2026-06-18","current":-37.558179,"twenty":-46.808807,"median":-17.769888,"eighty":-10.69486,"marketCap":12280660536},{"date":"2026-06-26","current":-39.595044,"twenty":-46.821444,"median":-17.818766,"eighty":-10.726786,"marketCap":12946668637},{"date":"2026-07-02","current":-40.024656,"twenty":-46.821444,"median":-17.854581,"eighty":-10.726786,"marketCap":13087141809},{"date":"2026-07-10","current":-32.483705,"twenty":-46.821444,"median":-17.871767,"eighty":-10.726786,"marketCap":10621424474},{"date":"2026-07-17","current":-27.621511,"twenty":-46.821444,"median":-17.880886,"eighty":-10.979464,"marketCap":9031598685},{"date":"2026-07-24","current":-28.23813,"twenty":-46.821444,"median":-17.925673,"eighty":-11.109046,"marketCap":9233219003},{"date":"2026-07-31","current":-15.666504,"twenty":-46.83029,"median":-17.93492,"eighty":-11.257113,"marketCap":8854300676},{"date":"2026-08-07","current":-16.022293,"twenty":-46.83029,"median":-17.93492,"eighty":-11.326236,"marketCap":9055383705},{"date":"2026-08-14","current":-16.42807,"twenty":-46.83029,"median":-17.93492,"eighty":-11.457268,"marketCap":9284718070},{"date":"2026-08-21","current":-17.277849,"twenty":-46.83029,"median":-17.93492,"eighty":-11.52511,"marketCap":9764990760},{"date":"2026-08-28","current":-18.356979,"twenty":-46.83029,"median":-17.973741,"eighty":-11.565738,"marketCap":10374887222},{"date":"2026-09-04","current":-17.092603,"twenty":-46.83029,"median":-17.982683,"eighty":-11.643516,"marketCap":9660294637},{"date":"2026-09-10","current":-16.472176,"twenty":-46.83029,"median":-17.982683,"eighty":-11.673442,"marketCap":9309645718}],"updateTime":1789130448418},"$inf$@#url:\"https://stock-news.skytigris.cn/v3/notice/important/events/list\",params:#symbol:\"IONS\",pageSize:20,pageCount:7,market:\"us\",,,undefined,":[{"items":[{"cdn_pdf":false,"hasAttachments":true,"id":"19945024","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000157-IONS","pdf_url":"","pub_time":1754280000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000157/0001972481-25-000157-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000157/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILECfvyLehtUoHHpQcU","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-08-04 12:00","pubTimestamp":1754280000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19928223","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401525000167-IONS","pdf_url":"","pub_time":1753848000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","titleType":"Quarterly Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/0000874015-25-000167-index.htm","us_notice_code":"Form 10-Q","us_title_en":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS, INC. 10-Q 6-30-2025","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/form10q.htm","primary":true,"translateUrl":"","linkName":"form10q.htm","type":"10-Q","id":"NTFILEC3cRydedycKDWhX2","market":"us","size":1299781},{"description":"EXHIBIT 10.1","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex10-1.htm","primary":false,"translateUrl":"","linkName":"ex10-1.htm","type":"EX-10.1","id":"NTFILE57em5Yc9bov5Q5de","market":"us","size":849146},{"description":"EXHIBIT 10.2","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex10-2.htm","primary":false,"translateUrl":"","linkName":"ex10-2.htm","type":"EX-10.2","id":"NTFILEF7gSqABfVi23WF3E","market":"us","size":68062},{"description":"EXHIBIT 10.3","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex10-3.htm","primary":false,"translateUrl":"","linkName":"ex10-3.htm","type":"EX-10.3","id":"NTFILEFaj2eFtFXVnwi2Jj","market":"us","size":25919},{"description":"EXHIBIT 10.4","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex10-4.htm","primary":false,"translateUrl":"","linkName":"ex10-4.htm","type":"EX-10.4","id":"NTFILE9A3buiwWfdk6U2kR","market":"us","size":38936},{"description":"EXHIBIT 10.5","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex10-5.htm","primary":false,"translateUrl":"","linkName":"ex10-5.htm","type":"EX-10.5","id":"NTFILEFuguNK78avqFiNs7","market":"us","size":18329},{"description":"EXHIBIT 10.6","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex10-6.htm","primary":false,"translateUrl":"","linkName":"ex10-6.htm","type":"EX-10.6","id":"NTFILECXA2gLCj3v1jK6q4","market":"us","size":961841},{"description":"EXHIBIT 10.7","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex10-7.htm","primary":false,"translateUrl":"","linkName":"ex10-7.htm","type":"EX-10.7","id":"NTFILEEFNeYCRfCGe9XV9F","market":"us","size":17551},{"description":"EXHIBIT 31.1","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex31-1.htm","primary":false,"translateUrl":"","linkName":"ex31-1.htm","type":"EX-31.1","id":"NTFILE5gTRvYXYBh3NVSiD","market":"us","size":8577},{"description":"EXHIBIT 31.2","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex31-2.htm","primary":false,"translateUrl":"","linkName":"ex31-2.htm","type":"EX-31.2","id":"NTFILEA7PVdwYXvLPwAsoc","market":"us","size":8504},{"description":"EXHIBIT 32.1","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/ex32-1.htm","primary":false,"translateUrl":"","linkName":"ex32-1.htm","type":"EX-32.1","id":"NTFILEENkRSP89QnLaW3TL","market":"us","size":4860},{"description":"","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000167/image01.jpg","primary":false,"translateUrl":"","linkName":"image01.jpg","type":"GRAPHIC","id":"NTFILE2QNHESKi9wufXtqE","market":"us","size":178113}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[],"event_type":"important_notice","event_name":"Quarterly Report","pubTime":"2025-07-30 12:00","pubTimestamp":1753848000,"title_zh":"Form 10-Q - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19928221","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125028020-IONS","pdf_url":"","pub_time":1753848000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form S-8 - Securities to be offered to employees in employee benefit plans","symbol":"IONS","title":"Form S-8 - Securities to be offered to employees in employee benefit plans","titleType":"Employee Stock Ownership","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125028020/0001140361-25-028020-index.htm","us_notice_code":"Form S-8","us_title_en":"Form S-8 - Securities to be offered to employees in employee benefit plans","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"S-8","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125028020/ef20052672_s8.htm","primary":true,"translateUrl":"","linkName":"ef20052672_s8.htm","type":"S-8","id":"NTFILECgUx4Ee6fPkkYvwf","market":"us","size":68222},{"description":"EXHIBIT 5.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125028020/ef20052672_ex5-1.htm","primary":false,"translateUrl":"","linkName":"ef20052672_ex5-1.htm","type":"EX-5.1","id":"NTFILEAmhXEovKBnVX6jqg","market":"us","size":5240},{"description":"EXHIBIT 23.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125028020/ef20052672_ex23-1.htm","primary":false,"translateUrl":"","linkName":"ef20052672_ex23-1.htm","type":"EX-23.1","id":"NTFILE386j5eyfa1RBZGmd","market":"us","size":1909},{"description":"","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125028020/ef20052672_ex107.htm","primary":false,"translateUrl":"","linkName":"ef20052672_ex107.htm","type":"EX-FILING FEES","id":"NTFILE2rHRnmFtodunKfPj","market":"us","size":17062}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Employee Stock Ownership","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Employee Stock Ownership","pubTime":"2025-07-30 12:00","pubTimestamp":1753848000,"title_zh":"Form S-8 - Securities to be offered to employees in employee benefit plans","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19928220","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000150-IONS","pdf_url":"","pub_time":1753848000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000150/0001972481-25-000150-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000150/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE8FruwPiqPHVKjszS","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-07-30 12:00","pubTimestamp":1753848000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19926913","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125027949-IONS","pdf_url":"","pub_time":1753848000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125027949/0001140361-25-027949-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125027949/ef20052929_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20052929_ex99-1.htm","type":"EX-99.1","id":"NTFILEBhcrrHuzT5bqTUtU","market":"us","size":426577},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125027949/ef20052929_8k.htm","primary":false,"translateUrl":"","linkName":"ef20052929_8k.htm","type":"8-K","id":"NTFILE6kD2JuMf3iy4Ax6e","market":"us","size":27294},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125027949/image0.jpg","primary":false,"translateUrl":"","linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILE5VMdTfY1reb9yesH","market":"us","size":24775}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-07-30 12:00","pubTimestamp":1753848000,"title_zh":"Form 8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19765070","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125022267-IONS","pdf_url":"","pub_time":1749700800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125022267/0001140361-25-022267-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125022267/ef20050532_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20050532_ex99-1.htm","type":"EX-99.1","id":"NTFILED5LCks4TmiFQR79z","market":"us","size":10296},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125022267/ef20050532_8k.htm","primary":false,"translateUrl":"","linkName":"ef20050532_8k.htm","type":"8-K","id":"NTFILE8EiVQ5W3xvXDkniB","market":"us","size":22726},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125022267/image00002.jpg","primary":false,"translateUrl":"","linkName":"image00002.jpg","type":"GRAPHIC","id":"NTFILE5xBVmCWcoNFqcv4A","market":"us","size":3600}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-06-12 12:00","pubTimestamp":1749700800,"title_zh":"Form 8-K - Current report","summary_en":"Item 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19755294","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125022001-IONS","pdf_url":"","pub_time":1749528000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125022001/0001140361-25-022001-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 5.07: Submission of Matters to a Vote of Security Holders;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"8-K","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125022001/ef20050437_8k.htm","primary":true,"translateUrl":"","linkName":"ef20050437_8k.htm","type":"8-K","id":"NTFILE9W2LXw9NBB4QsrQv","market":"us","size":42657}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-06-10 12:00","pubTimestamp":1749528000,"title_zh":"Form 8-K - Current report","summary_en":"Item 5.07: Submission of Matters to a Vote of Security Holders;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19663947","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125019620-IONS","pdf_url":"","pub_time":1747627200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125019620/0001140361-25-019620-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125019620/ef20049265_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20049265_ex99-1.htm","type":"EX-99.1","id":"NTFILE45XMEeVoKzKC5DUn","market":"us","size":18559},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125019620/ef20049265_8k.htm","primary":false,"translateUrl":"","linkName":"ef20049265_8k.htm","type":"8-K","id":"NTFILE2cL7cxSmo71EVAsJ","market":"us","size":27402},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125019620/image00001.jpg","primary":false,"translateUrl":"","linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILE8SKoqtJ6cYFzSH3G","market":"us","size":3513}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-05-19 12:00","pubTimestamp":1747627200,"title_zh":"Form 8-K - Current report","summary_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19587244","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401525000123-IONS","pdf_url":"","pub_time":1745985600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","titleType":"Quarterly Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000123/0000874015-25-000123-index.htm","us_notice_code":"Form 10-Q","us_title_en":"Form 10-Q - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS, INC. 10-Q 3-31-2025","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000123/form10q.htm","primary":true,"translateUrl":"","linkName":"form10q.htm","type":"10-Q","id":"NTFILE8VwqwT2fUMHRSgCp","market":"us","size":1531497},{"description":"EXHIBIT 10.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000123/ex10-1.htm","primary":false,"translateUrl":"","linkName":"ex10-1.htm","type":"EX-10.1","id":"NTFILE7tN3qJyYqC9HJBJg","market":"us","size":27770},{"description":"EXHIBIT 10.2","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000123/ex10-2.htm","primary":false,"translateUrl":"","linkName":"ex10-2.htm","type":"EX-10.2","id":"NTFILE4XNSuTFyjYcXdmgH","market":"us","size":903681},{"description":"EXHIBIT 31.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000123/ex31-1.htm","primary":false,"translateUrl":"","linkName":"ex31-1.htm","type":"EX-31.1","id":"NTFILEASAvDT98Pxvzj5RY","market":"us","size":12910},{"description":"EXHIBIT 31.2","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000123/ex31-2.htm","primary":false,"translateUrl":"","linkName":"ex31-2.htm","type":"EX-31.2","id":"NTFILEEF6dRLFsx77LGxdY","market":"us","size":12807},{"description":"EXHIBIT 32.1","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000123/ex32-1.htm","primary":false,"translateUrl":"","linkName":"ex32-1.htm","type":"EX-32.1","id":"NTFILE6WJxM6yqjxf9MHUc","market":"us","size":7028}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[],"event_type":"important_notice","event_name":"Quarterly Report","pubTime":"2025-04-30 12:00","pubTimestamp":1745985600,"title_zh":"Form 10-Q - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19586506","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125016562-IONS","pdf_url":"","pub_time":1745985600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125016562/0001140361-25-016562-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125016562/ef20048172_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20048172_ex99-1.htm","type":"EX-99.1","id":"NTFILE3zsr9taZChoQADDA","market":"us","size":303213},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125016562/ef20048172_8k.htm","primary":false,"translateUrl":"","linkName":"ef20048172_8k.htm","type":"8-K","id":"NTFILEHCFdbpAMh6pSkJr4","market":"us","size":27566},{"description":"null","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125016562/image0.jpg","primary":false,"translateUrl":"","linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEHbG2acwGUFb73dQ5","market":"us","size":24775}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-04-30 12:00","pubTimestamp":1745985600,"title_zh":"Form 8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19402983","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401525000108-IONS","pdf_url":"","pub_time":1744776000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000108/0000874015-25-000108-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000108/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE2qivBiA85xmTwVtN","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-04-16 12:00","pubTimestamp":1744776000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19402982","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401525000109-IONS","pdf_url":"","pub_time":1744776000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000109/0000874015-25-000109-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000109/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE74J52KGLCrP6nVQA","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-04-16 12:00","pubTimestamp":1744776000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19402979","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401525000107-IONS","pdf_url":"","pub_time":1744776000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000107/0000874015-25-000107-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000107/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEBhKAR9daJNWxos7M","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-04-16 12:00","pubTimestamp":1744776000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19233436","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125008178-IONS","pdf_url":"","pub_time":1741739930000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/0001140361-25-008178-index.html","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125008178/ef20045255_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20045255_ex99-1.htm","type":"EX-99.1","id":"NTFILEZUhmCaEHXzhcpXwx","market":"us","size":13600},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125008178/ef20045255_8k.htm","primary":false,"translateUrl":"","linkName":"ef20045255_8k.htm","type":"8-K","id":"NTFILE6uxZaZEzYTyBm23g","market":"us","size":26604},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125008178/image00001.jpg","primary":false,"translateUrl":"","linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILE24PCiN4Vt1d8aJjN","market":"us","size":3657}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-03-12 08:38","pubTimestamp":1741739930,"title_zh":"Form 8-K - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19228692","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000050-IONS","pdf_url":"","pub_time":1741723491000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/0001972481-25-000050-index.html","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000050/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEDmGcHRqAeZj5wHKF","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-03-12 04:04","pubTimestamp":1741723491,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19125823","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401525000089-IONS","pdf_url":"","pub_time":1739999199000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405]","symbol":"IONS","title":"Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405]","titleType":"Annual Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/0000874015-25-000089-index.html","us_notice_code":"Form 10-K","us_title_en":"Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS, INC. 10-K 12-31-2024","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/form10k.htm","primary":true,"translateUrl":"","linkName":"form10k.htm","type":"10-K","id":"NTFILE5A4uQRwFs6cevZHR","market":"us","size":3510645},{"description":"EXHIBIT 10.58","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/exhibit10-58.htm","primary":false,"translateUrl":"","linkName":"exhibit10-58.htm","type":"EX-10.58","id":"NTFILEB13hryiF2RWUrRkq","market":"us","size":261830},{"description":"EXHIBIT 19","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/exhibit19.htm","primary":false,"translateUrl":"","linkName":"exhibit19.htm","type":"EX-19","id":"NTFILEthGHFQo9mkwEr2QT","market":"us","size":30756},{"description":"EXHIBIT 23.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/exhibit23-1.htm","primary":false,"translateUrl":"","linkName":"exhibit23-1.htm","type":"EX-23.1","id":"NTFILEAgr5ejY2DJXfyJu7","market":"us","size":4575},{"description":"EXHIBIT 31.1","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/exhibit31-1.htm","primary":false,"translateUrl":"","linkName":"exhibit31-1.htm","type":"EX-31.1","id":"NTFILEDARufHGLYYRh8tJg","market":"us","size":12750},{"description":"EXHIBIT 31.2","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/exhibit31-2.htm","primary":false,"translateUrl":"","linkName":"exhibit31-2.htm","type":"EX-31.2","id":"NTFILE3rQw5dPiML9MffKR","market":"us","size":12758},{"description":"EXHIBIT 32.1","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/exhibit32-1.htm","primary":false,"translateUrl":"","linkName":"exhibit32-1.htm","type":"EX-32","id":"NTFILE7YFndhARdiZm35wC","market":"us","size":7304},{"description":"","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/image01.jpg","primary":false,"translateUrl":"","linkName":"image01.jpg","type":"GRAPHIC","id":"NTFILE8upF9Vxrp2yHkJ5y","market":"us","size":81780},{"description":"","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/image02.jpg","primary":false,"translateUrl":"","linkName":"image02.jpg","type":"GRAPHIC","id":"NTFILE3CTTKhy552LhX1J3","market":"us","size":101508},{"description":"","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/image03.jpg","primary":false,"translateUrl":"","linkName":"image03.jpg","type":"GRAPHIC","id":"NTFILE5RunsMRXehjnGVme","market":"us","size":111416},{"description":"","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000089/image04.jpg","primary":false,"translateUrl":"","linkName":"image04.jpg","type":"GRAPHIC","id":"NTFILEALiFdRnHpEYtnkpk","market":"us","size":181472}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Annual Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[],"event_type":"important_notice","event_name":"Annual Report","pubTime":"2025-02-20 05:06","pubTimestamp":1739999199,"title_zh":"Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19119995","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125005080-IONS","pdf_url":"","pub_time":1739941200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125005080/0001140361-25-005080-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125005080/ef20043828_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20043828_ex99-1.htm","type":"EX-99.1","id":"NTFILEu5WUvBkHM6RprfEk","market":"us","size":401887},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125005080/ef20043828_8k.htm","primary":false,"translateUrl":"","linkName":"ef20043828_8k.htm","type":"8-K","id":"NTFILECBWLptGRSAtbLfja","market":"us","size":27615},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125005080/image0.jpg","primary":false,"translateUrl":"","linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILE7qai8BWxnHZtcpvj","market":"us","size":24775}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-02-19 13:00","pubTimestamp":1739941200,"title_zh":"Form 8-K - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19120014","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000019-IONS","pdf_url":"","pub_time":1738645200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000019/0001972481-25-000019-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000019/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILECJdqW9eu61kZXyWt","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-02-04 13:00","pubTimestamp":1738645200,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19119996","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000020-IONS","pdf_url":"","pub_time":1738645200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000020/0001972481-25-000020-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000020/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE6mEkugyKX6xnogBW","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-02-04 13:00","pubTimestamp":1738645200,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"19091468","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401525000074-IONS","pdf_url":"","pub_time":1738299600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000074/0000874015-25-000074-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401525000074/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE4NcshFKjLJvhWYR9","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-01-31 13:00","pubTimestamp":1738299600,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0}],"pageSize":20,"totalPage":22,"pageCount":7,"totalSize":426,"code":"91000000","status":"200"}]}}