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SPYRE THERAPEUTICS INC

91.22

+2.512.83%

Volume:454.73K

Turnover:40.72M

Market Cap:8.04B

PE:-45.38

High:91.22

Open:89.99

Low:87.91

Close:88.71

52wk High:110.18

52wk Low:14.51

Shares:88.17M

Float Shares:80.98M

Volume Ratio:0.50

T/O Rate:0.56%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.0100

EPS(LYR):-1.9755

ROE:-22.98%

ROA:-19.81%

PB:8.42

PE(LYR):-46.18

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Overview Company News Filings

Spyre Therapeutics launches $300 million common stock offering

Spyre Therapeutics Announces Proposed Public Offering of Its Common Stock

THOMSON REUTERS

Spyre Therapeutics Inc - Suspends and Terminates Atm Prospectus for at-the-Market Offering Effective April 13, 2026 - SEC Filing

THOMSON REUTERS

Spyre data ‘exceptional,’ but combos could enable ‘dominance,’ says TD Cowen

Analysts’ Top Healthcare Picks: Oruka Therapeutics (ORKA), Spyre Therapeutics (SYRE)

Leerink sees Spyre’s SPY001 Phase 2 Data as incrementally positive for Oruka

Top Midday Gainers

MT Newswires Live

BUZZ-U.S. STOCKS ON THE MOVE-Conagra, Oracle, Replimune

Spyre Therapeutics rises 24.2%

BUZZ-U.S. STOCKS ON THE MOVE-Allogene Therapeutics, Adobe, Williams-Sonoma

Spyre Therapeutics Up Nearly 25%, on Track for Highest Close Since April 2022 -- Data Talk

Sector Update: Health Care

MT Newswires Live

Spyre Therapeutics Shares Surge 23% in Pre-Market Trading

Spyre Therapeutics Exec Says Spy001 Monotherapy Matched or Exceeded Efficacy Seen With Johnson & Johnson's Combination on Some Endpoints in Mid-Stage Study - Conf Call

THOMSON REUTERS

Spyre Shares up 23% Premarket After Co Says Inflammatory Bowel Drug Reduces Disease Activity in Mid-Stage Study

THOMSON REUTERS

Spyre Therapeutics Sees Positive Results From Ulcerative Colitis Trial

Spyre says SPY001 meets primary endpoint in Phase 2 ulcerative colitis trial

BRIEF-Spyre Therapeutics Reports Positive 12-Week Phase 2 Data For SPY001 In Skyline Trial

Spyre Announces Potential Best-in-Class Spy001 Part a Induction Results From Skyline Trial in Moderate-to-Severe Ulcerative Colitis Patients

THOMSON REUTERS

Spyre Therapeutics: Secondary Endpoints Included Clinical Remission by Modified Mayo Score of 40% & Endoscopic Improvement of 51%

THOMSON REUTERS

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ETF  0.2% lower and the iShares Biotechnology ETF  up 0.4%Spyre Therapeutics  shares were up more than 27% after the company said its SPY001 investigational treatment for moderate-to-severely active ulcerative colitis met its primary and key secondary endpoints in a phase 2 trial.","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["XBI","LABU","BK4588","BK4585","BK4139","SYRE","XLV","BK4581","IBB"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1139598559","title":"Spyre Therapeutics Shares Surge 23% in Pre-Market Trading","url":"https://stock-news.laohu8.com/highlight/detail?id=1139598559","media":"Deep 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19:25","pubTimestamp":1776079500,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics hit the key target in a trial of its candidate treatment for moderate to severely active ulcerative colitis.The clinical-stage biotechnology company said Monday it achieved positive 12-week induction data from the first part of its Phase 2 Skyline trial of SPY001.The study met its primary endpoint with a statistically significant reduction of 9.2 points from baseline at week 12 in a Robart's Histopathology Index score. Secondary endpoints included clinical remission by modified Mayo score of 40% and endoscopic improvement of 51%, Spyre said.Trading in Spyre's shares was halted ahead of the news.The company said recruitment for part A of Skyline is now closed and that enrollment is open for part B, which it said includes three monotherapy cohorts and three combination cohorts. Proof-of-concept induction data for the remaining cohorts of part A are now expected mid-2026 for SPY002 and in the third quarter for SPY003, Spyre said. Part B induction data for all cohorts re","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","BK4007","LENZ","BK4539","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2627159432","title":"Spyre says SPY001 meets primary endpoint in Phase 2 ulcerative colitis trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2627159432","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2627159432?lang=en_us&edition=fundamental","pubTime":"2026-04-13 19:03","pubTimestamp":1776078185,"startTime":"0","endTime":"0","summary":"Spyre reported positive 12-week induction results already presented from Part A of Phase 2 SKYLINE trial of SPY001 in moderate-to-severe ulcerative colitis.Study met primary goal, supporting meaningful improvement in disease activity versus baseline.Secondary measures also improved, reinforcing potential for a best-in-class profile.Safety profile was consistent with anti-α4β7 class, supporting continued development.Enrollment shifted to Part B, expanding evaluation of SPY001 as monotherapy and in combination, with additional proof-of-concept readouts expected mid-2026 and Q3 2026.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260413:nNDL6hYbmr:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SG9999014013.SGD","IE00BN0W2T93.GBP","SG9999014039.USD","IE00BN0W2W23.USD","IE00BKPKM429.USD","SG9999014021.USD","SG9999014005.SGD","LU0314104364.USD","LU2210149790.SGD","IE00B64PRP62.GBP","IE00BN0W2V16.EUR","IE00BGHQF748.EUR","NDAQ","SYRE","LU2210150020.SGD","IE00B3QW5Z07.USD","LU2095319765.USD","BK4585","BK4588","BK4112","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2627324864","title":"BRIEF-Spyre Therapeutics Reports Positive 12-Week Phase 2 Data For SPY001 In Skyline Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2627324864","media":"Reuters","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2627324864?lang=en_us&edition=fundamental","pubTime":"2026-04-13 19:00","pubTimestamp":1776078003,"startTime":"0","endTime":"0","summary":"BRIEF-Spyre Therapeutics Reports Positive 12-Week Phase 2 Data For SPY001 In Skyline TrialApril 13  - 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